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KMID : 0829220100340060383
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Korean Journal of Oral and Maxillofacial Pathology
2010 Volume.34 No. 6 p.383 ~ p.386
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A Case Report of Osteogenic Sarcoma Arising from Florid Osseous Dysplasia
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Kim Hyun-Sil
Kim Nam-Hee
Yook Jong-In
Kim Jin
Park Hyok
Cha In-Ho
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Abstract
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Osteogenic sarcoma is primary malignant bone tumor. It can arise de novo or from the benign precursors lesions, like Paget’s disease, giant cell tumor, chronic osteomyelitis, osteoblastoma, and fibrous dysplasia. Here, we present a case of osteogenic sarcoma arising from florid osseous dysplasia appearing as a rapidly growing bony bulging mass in 44-year-old Korean female who had at first been non-symptomatic, but later suffered from the numbness of chin and lower lip. The radiologic images revealed the mixed radiopaque- radiolucent intraosseous lesions throughout the mandible, which were diagnosed as florid osseous dysplasia pathologically. But only after 6 months, the lesions were substituted by the radiological ill-defined diffuse bony sclerotic lesion with bone destruction, accompanying the interrupted periosteal bone formation, which were pathologically diagnosed as osteogenic sarcomas. These serial clinicopathologic changes imply the malignant progression of florid osseous dysplasia rather than the collision of benign condition, florid osseous dysplasia and malignant tumor, osteogenic sarcoma. The possibility for fibro-osseous lesion of the jaw as premalignant lesion should not be overlooked; therefore, periodic check-ups for the lesions are necessary. Proper evaluation and interpretation for clinical neural symptom and radiologic change of bone density may lead to the correct differential diagnosis and therapeutic intervention.
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KEYWORD
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Florid osseous dysplasia, Osteogenic sarcoma, Premalignant lesion, Fibro-osseous lesion
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